After she got married, she retired from her acting career.
Until discovered by Fellini, Milo had mostly performed in comedies and melodramas. Although she was reluctant to make a comeback, Fellini convinced her to take on the role of the sexy, lightheaded mistress opposite Marcello Mastroianni in 8½. The movie, which won universal acclaim, failed to change the public perception of her and although she was cast in Juliet of the Spirits, most of her following endeavors were second-rate films. In the mid-1960s, Milo was hostess of a television program in Rome. She retired again from acting in 1968, only to make a second comeback in 1979. Her roles have shifted from that of the temptress to more stern middle-aged women. In 2006-07 she toured Italy with the theatrical adaptation of 8 Women.
She married Moris Ergas with whom she had a daughter Deborah, and later married Ottavio De Lollis with whom she had two children, Ciro and Azzurra.